What is hyaluronidase made from?

Hyaluronidase is injected with a very thin needle along with the local anesthetic, lidocaine, into the area where the filler needs to be dissolved. Hyaluronidase only works on fillers composed of hyaluronic acid, and are not suitable for fillers like Radiesse or Sculptra.

Hyaluronidases are found in the venom of certain lizards and snakes, as well as honeybees, where they are referred to as “spreading factors”, having a function akin to bacterial hyaluronidases.

Furthermore, does hyaluronidase dissolve your own tissue? I’ll start with the easier one first: hyaluronidase does not destroy your own tissue in any way. Hyaluronidase is an enzyme (found naturally in your body that breaks hyaluronic acid (HA) down. Hyaluronidase will remove the filler 100% if you place it on or as close as possible to the injected filler.

Then, what is hyaluronidase used for?

Hyaluronidase is used together with fluids injected into the body to treat dehydration. Hyaluronidase can also be used as an aid in helping your body absorb other injected medications. Hyaluronidase is also used to help contrast dyes in your body show more clearly on certain types of x-rays or scans.

What type of agent is hyaluronidase?

Hyaluronidase (Hylase Dessau®) is a hyaluronic acid-metabolizing enzyme, which has been shown to enhance drug diffusion and thereby increasing the efficacy of local anesthetics. It is used in management of lower eyelid edema associated with cosmetic procedure.

Is hyaluronidase dangerous?

It is important to note that there are some side effects to hyaluronidase you need to be aware of. The most common side effect is swelling and bruising. This usually settles down a few days after the treatment. While allergy in the injection area is very rare, it can be severe and may include the risk of anaphylaxis.

How long does hyaluronidase stay in the body?

When injected, hyaluronidase has an immediate working effect on HA in tissue. It is known to have a half-life of around two minutes, however, its duration of action is longer at around 48 hours.

Does hyaluronidase dissolve collagen?

Hyaluronidase. Although Hyaluronidase is a pesky enzyme that breaks down collagen in the skin. It destroys the natural hyaluronic acid created in the body, therefore disabling it from binding collagen and elastin molecules.

What are the side effects of hyaluronidase?

Hyaluronidase Side Effects Cough. difficulty swallowing. dizziness. fast heartbeat. hives or welts. itching. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue.

How much hyaluronidase does it take to dissolve Juvederm?

How much hyaluronidase should you use? Some use 150 units per mL; A simple rule of thumb for each 10th of a cc of Restylane, use about 5 units of Vitrase; (remember that the units across every brand may not be the same); 10 units if you’re trying to dissolve Juvederm; and probably about 15 units for Voluma.

Is hyaluronidase painful?

After the procedure some other common injection-related reactions might occur. These reactions include redness, swelling, pain, itching, bruising and tenderness at the injection site. They have generally been described as mild to moderate and typically resolve spontaneously after a few days after injection.

Does hyaluronidase cause swelling?

Amphadase (hyaluronidase) is a genetically designed protein used as an aid in helping your body absorb other injected medications. Common side effects of Amphadase include: injection site reactions (pain, itching, redness, tenderness, or swelling) swelling in any part of the body.

How much does hyaluronidase cost?

Each round of hyaluronidase costs between $100-$200 for the enzyme injection, depending on how much is needed. It may require more than one session to achieve adequate filler dissolving.

Does hyaluronidase work immediately?

Hyaluronidase works very quickly, with most of the effect taking place within 24 hours. You should be able to see defined improvement and less filler in the area injected, beginning within a few hours. For denser, more cross-linked products, it may take 48 to 72hours to dissolve.

Does hyaluronidase dissolve Botox?

A liquid called Hyaluronidase is injected into the area in the same way as Botox or filler. “The product starts to dissolve within minutes and continues for a few days,” says Dr Ravi Jain.

Does hyaluronidase spread?

Since hyaluronidases are enzymes that catalyze the breakdown of hyaluronic acid in the body, they may increase the permeability of tissue to fluids. Hyaluronidase in snake and insect venom is thought to function as a “spreading factor” by degrading host hyaluronic acid, thus allowing spread of toxin (13).

Can hyaluronidase cause blindness?

Blindness caused by ophthalmic artery embolism is the most catastrophic complication of facial hyaluronic acid (HA) injections. Extravascular (retrobulbar) injection of hyaluronidase has been suggested as a salvage in this calamitous situation. However, the effectiveness of this treatment still lacks consensus.

Can you partially dissolve lip filler?

Hyaluronic acid fillers, such as Juvéderm products (including VOLUMA and VOLBELLA), Restylane products, and Belotero, can be partially or completely removed with an enzyme called hyaluronidase.

Does hyaluronidase need to be refrigerated?

Vitrase: Store intact vials in refrigerator at 2°C to 8°C (36°F to 46°F); do not freeze. Protect from light. If adding to other injectable solutions, store admixture at 15°C to 25°C (59°F to 77°F) and use within 6 hours.